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Activity Number: 324
Type: Contributed
Date/Time: Tuesday, August 5, 2008 : 2:00 PM to 3:50 PM
Sponsor: Biopharmaceutical Section
Abstract - #301101
Title: Hypothesis Testing with a Buffer Area
Author(s): Boshao Zhang*+
Companies: Medical University of South Carolina
Address: 135 Cannon Street , Charleston, SC, 29403,
Keywords: sample size ; hypothesis testing ; clinical significance ; quality control
Abstract:

A testing strategy is proposed to avoid the ambiguity of a "negative result." It distinguishes important effects from those in a buffer area. If a result falls into the buffer area, the effect can be declared positive with a probability, or declared as pending. There may be clinical uses. For example, a new blood pressure lowering drug is tested with mean 145 mm Hg, sd 13 mm Hg for the study group. A buffer is set for reduction between 4 and 10 mm. Sample size can be calculated for conventional testing, but a test with a buffer area yields a markedly reduced sample size.


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