TL45: Mediators and Moderators in Randomized Clinical Trials
*Qing Liu, Johnson & Johnson Janssen Research & Development, LLC  Isaac Nuamah, Janssen R&D  Christine Blasey, Corcept Therapeutics and Stanford University 


Datasets for clinical trials provide an opportunity to analyze both moderators and mediators of the treatment effect. Because multiple models exist which define these correlates of treatment response, there is often disagreement regarding how to statistically test for mediators and moderators. We will discuss and share ideas regarding how to conduct such analyses(e.g. the McArthur model, Barron and Kenny), and how to use the results to guide future trials.