Several modifiable risk factors have been identified for colorectal cancer (CRC), the second leading cause of cancer death in the US. We developed models to estimate the probability of first incidence of proximal, distal or rectal cancer in White men and women, aged 50+ years. We 1) estimated relative risk parameters from population-based case-control data separately for proximal, distal, and rectal cancer; 2) estimated baseline age-specific cancer hazard rates based on SEER incidence rates and attributable risks; and 3) combined competing risks from national mortality rates, relative risks and baseline hazards to estimate the probability of developing the first of proximal, distal or rectal cancer over a pre-specified time interval (e.g., 5 or 10 years) given age and risk factors. We derived the variance of the risk estimates. Relative risks differed by gender and tumor site.